Originally Posted by RedXray

If you have HP Tuners you could easily flash in a "tow tune" with some timing pulled in both the high & low octane tables. A quick flash in just a matter of seconds (if your scans are detecting knock). You could also adjust the "shift scheduled" under the performance tables (tow/haul button) to keep the engine at a higher RPM during up/down shifts. This will help keep the engine out knock by eliminating any low RPM lugging situations. Towing only 10 times a year there are workarounds to be able to enjoy a nice compression ratio without hurting the engine... If you have the device.

Originally Posted by madmann26

A few of the biggest crutches with truck tunes:

1. TQ management
2. Burst Knock
3. Overly sensitive knock sensor settings

For me and because I have the 80e, I turned off TQ management.

I use the 02-04 z06 knock sensor values and make the recovery from knock react faster.

I disable burst knock.